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KMID : 0043320100330040503
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Archives of Pharmacal Research
2010 Volume.33 No. 4 p.503 ~ p.508
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Chemical Components from the Vietnamese Soft Coral Lobophytum sp.
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Kim Young-Ho
Tung Nguyen Huu
Minh Chau Van
Kiem Phan Van
Huong Hoang Thanh
Nam Nguyen Hoai
Cuong Nguyen Xuan
Quang Tran Hong
Nhiem Nguyen Xuan
Hyun Jae-Hee
Kang Hee-Kyoung
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Abstract
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Chromatographic separation resulted in the identification of one new squalene derivative, named lobophytene (1), three cembranoid diterpenes (2-4), and two sterols (5 and 6) from the Vietnamese marine soft coral Lobophytum sp. Their structures were identified on the basis of extensive spectroscopic data and comparison of those with reported data. Compounds 1 and 2 showed significant cytotoxic activities against lung (A549) and colon (HT-29) cell lines with IC50 values of 8.2 and 5.6 μM for 1; 5.1 and 1.8 μM for 2, respectively.
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KEYWORD
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Soft coral, Lobophytum sp., Lobophytene, Cytotoxic activity
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